The cranial vault is composed by three bone layers (inner table, diploe, outer table), and its principal function is to safeguard the brain from impacts. Bone thickness is a crucial parameter to understand the biomechanical factors contributing to skull deformations and fractures after head injury. It is therefore important to establish an accurate measurement system to quantify its variation. Lillie et al., 2015 analyzed microCT scans of two cadavers to evaluate the accuracy of the estimated cortical thickness from clinical CT data. Microscans were acquired at 25-microns, while CT scans had a resolution of 0.48-0.62 mm. The skull average thickness in both cases was below 4 mm. Cortical thickness measurements obtained from CT scans are more accurate compared with traditional physical methods, although results are comparable with those available in literature. The average cortical thickness discrepancy between microCT scans (higher resolution) and CT scans (lower resolution) is 0.078+ 0.58 mm. Such methodological validation is necessary when dealing with age-related changes in distribution of the skull cortical thickness, and to identify species-specific or population differences.
Gizéh Rangel de Lázaro